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ACEs are defined as potentially traumatic events that occur in childhood (0-17 years). ACEs can include witnessing or experiencing violence, being neglected or abused, growing up in a family with substance use disorders, or having a parent who is incarcerated

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Because GSH status is dynamic, the outcome measures were extended beyond GSH status alone to include 8-OHdG and F2-isoprostanes (F2-isoP), in case a change in oxidation status was exemplified by evidence of reduced oxidation products rather than a change in GSH or GSH:GSSG ratio (i.e., improvement in tissue-level oxidative stress not represented by RBC indices)

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I appreciate, John