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Deficiency can also lead to raised levels of a substance called homocysteine, which can increase the risk of heart disease and stroke

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Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification
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doi: 10.1016/0002-9343(81)90392-2

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