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GlyNAC (glycine and N-acetylcysteine) supplementation in old mice improves brain glutathione deficiency, oxidative stress, glucose uptake, mitochondrial dysfunction, genomic damage, inflammation and neurotrophic factors to reverse age-associated cognitive decline: implications for improving brain health in aging

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Quercetin and other polyphenols inhibit NLRP3 inflammasome assembly, thereby reducing caspase-1 activation and limiting the release of (IL-1, IL-18), this results in a significant reduction in neuroinflammatory cytotoxicity (Xue et al., 2017)
