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It is hypothesized that three main functions of autophagy may contribute to cellular protection: (a) buffering cellular stress in the presence of fluctuating nutrient supply by strengthening substrates that provide bioenergetic and anabolic responses

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2.6 Acidic pH-responsive small molecule prodrugs Due to the high glycolytic metabolism of cancer cells, their microenvironment tends to be acidic (pH 6.57.2), a key feature of cancers (Piasentin et al., 2020)

He and Giusti, 2010)