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On the other hand, despite sCT-induced neuronal activation in the AP of RAMP 1/3 KO HFD-fed mice, it did not result in an anorectic effect on day 1 of treatment suggesting the necessity of AMY 1 R and AMY 3 R to induce anorexia and that this circuitry is independent of signalling at the core CTR receptor

Stage 1: One side of body is affected Stage 2: Both sides of body affected but balance remains intact Stage 2.5: Both sides of body affected with mild impairment of balance Stage 3: Bilateral disease with impaired balance but functioning intact Stage 4: Moderate to severe bilateral disease

Medical writing and editorial support were provided by Murray Edmunds and Helen Marshall of Watermeadow Medical, part of the Ashfield Group, supported by Novo Nordisk A/S

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