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This interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (CGRP), pituitary adenylate cyclase activating polypeptide (PACAP) and/or cortical spreading depression (CSD) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (NLRP3) inflammasome formation, activated microglia, and reactive astrocytes

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Beyond hair and skin care, GHK-Cu has been linked to improved immune function, reduced inflammation, and protects against age-related diseases

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378 Astrocytic overload with iron however significantly reduces glutamate clearance by down-regulation expression of EAAT1 glutamate transporters 379 and impairs operation of the glymphatic system