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Acknowledgments The authors would like to thank the staff at the Animal Care Facilities at the University of Virginia and Case Western Reserve University for their expert and caring technical assistance in helping with the rats and individual experiments (scoring of withdrawal phenomena)

and glutathione S-transferase pi 1, GSTP1 , rs4147581 were genotyped by TaqMan-based allelic discrimination assay (Applied Biosystems, USA) using a CFX96 Touch Real-Time PCR detection system (Bio-Rad, USA)

Furthermore, compromised oligodendrocyte and myelin degeneration have been observed in patients with multiple sclerosis, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis [30-33]

doi: 10.1016/j.indcrop.2023.117744

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In the SURMOUNT trials for obesity, gastrointestinal adverse events increased with dose: 39% at 5 mg, 46% at 10 mg, and 49% at the 15 mg dose