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Fidarestat administered in drinking water significantly reduced azoxymethane (AOM)-induced premalignant lesions in the colon of C57BL/KsJ-db/db obese mice accompanied by downregulation of PKC-2, AKT, COX-2, and iNOS in the colonic mucosa, and decreased serum levels of IL-1, IP-10, MIG, TNF- and VEGF

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Cancer Lett2024 Feb 1:582:216515

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after a median of 12.4 years of monitoring, those in the highest quartiles of baseline CAC scores and carotid artery plaque burden had 15% and 23% higher risk of death for any reason, respectively, compared with those in the lowest quartiles

Current evidence comes primarily from laboratory and animal research