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1 are shown the main regulatory factors of the IGF-1 signaling, as well as the principal downstream pathways related to kidney hypertrophy

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For instance, variants in the CARD15 and LRRK2 genes are implicated in the pathogenesis of both conditions [114, 115]

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AP2/ERF APETALA2/ethylene-responsive element (AP2/ERF) binding factors are critical for regulating plant responses to abiotic stress and improving crop yields, and they make up one of the most evolutionarily ancient and expansive groups of TFs in plants

This complexity may explain why many treatment strategies and experimental methods have not been successful in SCRI treatment