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Patients often show serum concentrations toward the upper normal range in association with hypercalciuria [108]
Structurefunction studies of claudin extracellular domains by cysteine-scanning mutagenesis
36,132 QPI-1007 is a caspase-2-targeted siRNA without formulation that was developed to treat acute primary angle closure glaucoma (phase 2) and nonarteritic anterior ischemic optic neuropathy (NAION, phase 3)
Rinaldi R, De Nucci S, Castellana F, Di Chito M, Giannuzzi V, Shahini E, Zupo R, Lampignano L, Piazzolla G, Triggiani V, et al
PLOS ONE 13 , e0195283 (2018)
In addition to modifying self-antigens, free radicals can directly damage tissues, triggering inflammation and immune activation [58]
