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The combination of PBD and an antibody against ApoD demonstrated a senolytic readout by eliminating senescent fibroblasts without any effect on young cells
Gastrointestinal adverse events occurred in 79.6% of CagriSema participants versus 39.9% with placebo, were mostly transient, and led to discontinuation in 6-8.4% of participants
Interleukin-10-deficient mice develop chronic enterocolitis
BMC Neurosci
Despite this, there is no conclusive evidence that IGF-1 can modify cardiomyocytes in healthy heart tissue in addition to its observed overexpression (75, 83)
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