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Besides, EpCAM overexpression is related to Wnt/-catenin pathway activation in cancers, which is a potential causal pathway for cytoplasmic and nuclear accumulation of -catenin, indicating proliferation and reduced apoptosis in cancer cells [141]

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14 It recommends rapid initiation of alternate-day intramuscular hydroxocobalamin therapy, and maintenance of this treatment until all symptoms have resolved or there is no further neurological improvement, with long term B 12 therapy depending on the presence of deficiency on presentation, together with total abstinence from the use of nitrous oxide