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[DOI] [PubMed] [Google Scholar] 22.Papakostas G.I., Petersen T., Mischoulon D., Green C.H., Nierenberg A.A., Bottiglieri T., Rosenbaum J.F., Alpert J.E., Fava M

B 11 , 40324044 (2021)

The presence of ROS/RNS can activate the signaling pathways, including p53, mitogen-activated protein kinases (MAPK), Janus kinase-signal transducer and activator of transcription (JAK-STAT), and AKT pathways, leading to apoptosis [24]

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This process is catalyzed primarily by the same UGT1A1 enzyme on the endoplasmic reticulum, although a second enzyme, located in the canalicular portion of the hepatocyte plasma cell membrane, UDP-glucuronate glucuronosyltransferase (transglucuronidase), may also play a role