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5 Conclusion In summary, SLE is a complex chronic disease for which its pathophysiology and effective treatments remain speculative

In an endothelium-independent way, CGRP, due to its receptors, causes adenylate cyclase activation and cAMP increase, which activates protein kinase A (PKA), and this, in turn, phosphorylates ATP-dependent K+ channels, which leads to Ca 2+ sequestration mechanisms and causes smooth muscle relaxation

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But doctors point out these experimental compounds are highly unregulated and not ready for prime time

About Dr Shirin Lakhani Dr Shirin Lakhani is the founder and medical director of Elite Aesthetics
