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According to the US Food and Drug Administration, Betnesol is a category C drug, which means animal studies have shown adverse effects on the unborn, and there are no well-controlled studies in humans (5)

The rats in the S-AM and ABX + S-AM groups were administrated corresponding dose of S-amlodipine (0.6 ~ 5 mg/kg) once daily for 7 weeks by oral gavage, and the same dose of placebo was administered to the CK and ABX groups using the same procedure

|| The partial Mayo Clinic score consists of the Mayo Clinic score minus the sigmoidoscopy subscore

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doi: 10.1016/j.freeradbiomed.2004.04.035