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Extracellular iron is taken up by cells and transported to the mitochondria, where it is utilized for the synthesis of cofactors including heme and iron-sulfur (Fe/S) clusters essential to the function of enzymes involved in oxidation-reduction reactions, DNA synthesis and repair, and a variety of other cellular processes [76]

Subsequently, 1 mL of 4% (w/v) sodium hydroxide (NaOH) was introduced, and the final volume was adjusted to 2.5 mL with distilled water

GH stimulates in vitro T and B-cell proliferation and immunoglobulin synthesis, enhances human myeloid progenitor cell maturation, and modulates in vivo Th1/Th2 (8) and humoral immune responses (49)

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This can lead to poor or weak drug effects and readouts in different cell types or layers into the organoid

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