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Target concentration An estimate of a drugs volume of distribution and the con- centration range that is associated with the desired clinical response can be used to calculate the loading dose that would achieve the target concentration in a particular patient

In this review, we summarized results from currently available in vivo and in vitro studies of multiple eye disease models, clarified the pathological role and molecular mechanism of ferroptosis in retinal diseases, summed up the existing pharmacological agents targeting ferroptosis in retinal diseases as well as highlighting where future research efforts should be directed for the application of ferroptosis targeting agents

10.1093/jn/130.5.1200 161 OlthofM

Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange