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Crawford Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2022

To understand if carnitine can also promote glucose dependent de novo lipogenesis outside of the DKO context, we tested the impact of carnitine supplementation on WT and ACLY KO cells

doi:10.1016/j.heliyon.2023.e12963 Ikonomidis I, Katogiannis K, Chania C, et al

The cardiovascular support mechanisms of this modified amino acid involve comprehensive enhancement of myocardial energy production and vascular endothelial function

There are still concerns about the safety of creatine supplementation, particularly in relation to kidney function, although many studies have not observed any significant changes in important renal markers, including mGFR, cystatin C, proteinuria, or albuminuria

In conclusion, we found that ALC significantly reduced SREBP2 and HMGCR expression, leading to decreased de novo cholesterol synthesis, lower serum cholesterol levels in HCD-fed mice, and attenuated atherosclerotic progression