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10.1186/s40478-021-01288-2 106 MarreiroD
[DOI] [PMC free article] [PubMed] [Google Scholar] 238.Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP

These substances not only induce physical dependence and psychological addiction but also contribute to severe neurotoxicity, manifesting as persistent cognitive impairment, emotional instability, and motor dysfunction

An overview review was published in PMC in 2025 (PMC11943447)
But there is very little data on how the drug works in humans

Anat Embryol 166:6786 Braak H, Braak E (1983b) Neuronal types in the basolateral amygdaloid nuclei of man