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MATERIALS AND METHODS Animals Wistar Albino male rats (200 g b.w.) were randomly assigned to the experiments (10 animals at least per each experimental group and interval), all of which along with study protocol were approved by the Local Ethics Committee at the School of Medicine (University of Zagreb, Zagreb, Croatia)(380-59-10106-17-100/273)

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N -acetylcysteine: pharmacological considerations and experimental and clinical applications