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Trials administering oral or intravenous arginine and citrulline have reported improvements in uteroplacental hemodynamics and gestational blood-pressure control, without documenting teratogenicity or major maternal complications

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Notably, normal rats exhibited a portal pressure of 35 mmHg[25] similar to that of the inferior vena cava, though with at least 1 mmHg higher values in the portal vein

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