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Claudin-2-mediated cation and water transport share a common pore

This opens the door to more reliable and effective oral-use studies, a field of research that was previously hamstrung by the compound's fragility

The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

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L-NAME initially caused all vessels to disappear more rapidly and L-arginine increased the number of vessels (L-NAME R, L-arginine R, opposite ), but both induced larger pale areas (L-NAME R, L-arginine R, parallel ), all as NO-specific (NO-related) effects, as L-NAME and L-arginine regularly attenuated or antagonized each others responses (L-NAME R, L-arginine R, opposite , specific

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