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Specifically, acute and chronic prolonged wakefulness in mice induced by modafinil treatment produced LTP of glutamatergic synapses on hypocretin/orexin neurons in the lateral hypothalamus, a well-established arousal/wake-promoting center

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The organoids were introduced into the kidney capsule either with ECM with fibroblast growth factor 2 (FGF2) or as pure organoids without ECM/FGF2
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