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In summary, our data provide new insights into the effects of tesofensine on weight loss and the underlying neuronal mechanisms, suggesting that tesofensine may be an effective treatment for obesity and that it may be a valuable adjunct to other appetite suppressants to prevent body weight rebound

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Iron metabolism disorder, lipid peroxidation and decreased antioxidant capacity are involved in the occurrence of ferroptosis, and several key regulators (e.g., system Xc - , GPX4, p53 and ACSL4) play an important role in monitoring ferroptosis

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For HeLa cells a volume of 1,8003,600 m 3 per cell can be assumed 21 , yielding an intracellular GSH concentration of 7.715.5 mM