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Trends Genet 35 , 215222 (2019)

If a neuroleptic is deemed necessary, an agent with a more favorable adverse effect profile at the lowest possible dose is recommended

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For instance, complex I deficiency and the consequent increase in mitochondrial reactive oxygen species (ROS) play a critical role in the death of dopaminergic neurons in Parkinson's disease [5, 6]

Similarly, the linear curves at GSH concentration ranges of 40~400 (Figure 4c) and 4~40 (Figure 4d) M were also obtained by using 100 and 10 M ECA as the internal standards, respectively