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However, the gradual correction of anemia takes place over a period of 90 days
Zhou et al., 2023[170])
L., Brown, T
This approach not only enhances the efficacy of drugs but also minimizes side effects
By inhibiting CD38 activity in astrocytes genetically or pharmacologically, NAD + levels were increased, transcriptional reprogramming was inhibited, and monocyte chemotactic activity was impaired [49]
What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions
