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Targeting specific signaling pathways, such as JAK/STAT, PI3K/AKT, and NF-B, which regulate TAM polarization, along with innovative strategies like nanocarriers, exosomes, and CAR-macrophage therapy, could significantly improve the efficacy of cancer treatments, particularly in solid tumors where immunosuppression is a major challenge (155)

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This technique was first used in an attempt to rejuvenate the oocytes of older women with the cytoplasm from the oocytes of younger women thus increasing their fertility

Hydroperoxyl radicals play an essential role in lipid peroxidation, wherein this protonated form of O 2 - produces H 2 O 2 , which can react with redox-active metals, yielding HO