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Similar content being viewed by others Introduction L-ergothioneine (2-mercaptohistidine trimethylbetaine, C 9 H 15 N 3 O 2 S
Glutathione levels are decreased via xCT inhibition due to the deprivation of cellular Cys, and enzymes that require GSH are disabled

Falchook G, Duvic M, Hong D, Wheler J, Naing A, Lim J, et al

Johns wort extract, which resulted in lower striatal malondialdehyde levels, increased catalase activity, decreased glutathione (GSH) content, normalized Glial fibrillary acidic protein (GFAP) and tumor necrosis factor alpha or TNF- expression, reduced Deoxyribonucleic acid (DNA) fragmentation, and prevented dopaminergic neuron damage (Kiasalari et al., 2016)
doi: 10.1152/ajpendo.00073.2004

Collectively, MO could attenuate the negative impact of the chronic inflammation mainly through inhibiting the expression of a series of pro-inflammatory factors