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The fasting C-peptide/glucose ratio was used as a surrogate measurement for beta cell function, with a decrease interpreted as an indication of probable disease progression [12]

1,15 Hyperglycemia-induced metabolic pathways Polyol pathway activation In a hyperglycemic state, excess glucose is shunted into the polyol pathway, where aldose reductase catalyzes its reduction to sorbitol, which in turn is oxidized to fructose by sorbitol dehydrogenase

Berchtold M

Basically, kind of like an SOS, help me, BPC responds to that signal

Le Roux C, Steen O, Lucas KJ, Startseva E, Unseld A, Hennige AM

Most people with chronic symptoms are dealing with both