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Developmental Cell, 31 (5), 640653

There was evidence that mice without efficient expression of SOD2 enzyme resulted in significant epidermal thinning. In humans mitochondrial dysfunction promotes cellular senescence in epidermal keratinocytes in culture. [7] This means because of senescence, there were fewer cells in the epidermis, causing it to be thinner

Similarly, the oligochaete annelid Enchytraeus crypticus plays an important role in soil ecology through nutrient cycling

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While tirzepatide does not directly cause specific micronutrient deficiencies through its mechanism of action, the secondary effects on eating patterns and gastrointestinal function warrant attention to nutritional adequacy
