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Biochemical modulation of Cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance

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Its diverse manifestations, erratic course and prognosis, and inconsistent responsiveness to therapy pose a challenge to its detection, diagnosis, and management (Sabella, 2018)

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Yet, mutants deficient in SAP1-3, SAP4-6 or SAP9-10 were not compromised in their response to albumin, suggesting redundancy between fungal yeast and hyphae associated proteases as well as host proteases