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4-HNE also regulates the Nrf2 pathway by binding to Keap1, its cytosolic inhibitor, promoting its release and allowing Nrf2 nuclear translocation

[DOI] [PMC free article] [PubMed] [Google Scholar] 187.Huang X, Huang L, Ma C, Hong M, Xu L, Ju Y, et al

10.5281/zenodo.3926048

Although in the normal adult human brain the level of 3R-tau is similar to that of 4R-tau, immunocytochemistry and biochemical analysis indicate that the ratio of 3R- to 4R-tau is altered in AD and other neurodegenerative disorders (191)

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