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The resulting catastrophic energy deficit is a primary physiological driver of post-exertional malaise (PEM) or 'crashes,' where even minor, everyday activities trigger a disproportionate and prolonged exacerbation of profound fatigue, muscle weakness, and cognitive impairment

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T-cell-independent type 2 antigens are identified as very repetitive structures, that include cell membrane polysaccharides and bacterial flagella, that can crosslink B cell receptors to induce an IgM response (224)

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