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Compared to GLP-1 agonists GLP-1 receptor agonists like semaglutide and tirzepatide have become extremely popular for weight loss

References Dimet-Wiley, A., Wu, Q., Wiley, J., Eswar, A., Neelakantan, H., Savidge, T., & Watowich, S

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[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses