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Additionally, berberine can reverse drug resistance by activating AMPK, which is involved in cellular energy homeostasis

Application of melatonin in maintaining post harvest quality of fruits and vegetables: a review

This could be at least in part due to direct inhibition of cGMP phosphodiesterase (PDE5) activity, leading to an increase in the half-life of cGMP [170]

Nature 397 , 579583 (1999)
12 , e1002 (2022)