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This energy shortage impacts the hypothalamus, a key "circuit breaker" that regulates numerous bodily functions

reduced oral intake

Our previous study revealed that GSTM1 was required for the optimal activation of NF-B, a critical transcription factor for the expression of pro-inflammatory genes downstream of TNF- signaling ( via S -glutathionylation ( GSTM1 in astrocytes may also be involved in aging-associated changes in the brain and possibly aging-associated neurodegenerative diseases