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In addition to the insulin-stimulated differences in protein phosphorylation, many phosphosites detected in the phosphoproteomics are altered under basal conditions by changing leucine at position 973 to phenylalanine

The downregulation of SLC40A1 and FTH1 impairs iron export and storage, respectively, leading to intracellular iron accumulation, which in turn promotes Fenton reactions, lipid peroxidation, and ROS generation

Current research on bile acidinduced lipid peroxidation mainly emphasizes ROS generation, with ferroptosis and lipid peroxidation interconnected via the GSH/GSSG system and ROS balance

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Exogenous supplementation of NAC or GSH reduced the expression of NRF2 and GCLC, suggesting the NRF2/GCLC-related antioxidant production pathway might be desensitized