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Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, et al

The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

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This could enable the treatment of hypoxic tumors, which represent a major challenge in anticancer drug development

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