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Endogenous -synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity

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The UMAP visualization showed a skewness, with compounds categorized as drugs present on the right-hand side of the U1 axis and compounds categorized as metabolites on the left (Figure 2C)

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Such findings have led to the consideration of administering natural substances at low doses as part of a new drug-delivery system to improve bioavailability and brain penetrance