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Cachexia pathophysiology: Driven by pro-inflammatory cytokines TNF-, IL-1, IL-6, IFN- released by the underlying disease (tumor, failing heart, inflamed lung)

Jun 2020;23(3):213-223

Gaidamauskas E, Gyrup C, Boldt HB, Schack VR, Overgaard MT, Laursen LS, Oxvig C.IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): multiple PAPP-A-IGFBP interaction sites

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