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Certain health conditions, medications, and personal circumstances make it risky for some people
[DOI] [PubMed] [Google Scholar] 55.Case D.A., Darden T.A., Cheatham T.E

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Yes, daily supplementation is safe at doses between 250 and 500 mg for most adults
HUBERMAN: If you play sports or if you exercise frequently, sooner or later, people tend to get injured

Understanding alternatives helps contextualize when this combination makes sense
