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Ahn KS, Sethi G, Jain AK, Jaiswal AK, Aggarwal BB (2006) Genetic deletion of NAD(P)H:Quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, Ikappa Balpha kinase, c-Jun N-terminal kinase, Akt, p38 and p44/42 mitogen-activated protein kinases and potentiates apoptosis

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Following proteolytic cleavage of Notch by -secretase (an instrumental proteolytic enzyme in the Notch pathway), the active NICD fragment is translocated to the nucleus, where it induces the transcription of Notch target genes through interaction with CSL transcriptional regulators [120]