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The second mechanism, namely the drug induction mechanism hypothesis, is associated with secondary cancer resistance

Although NRPS product assembly frequently seems to display a strict correlation between the enzymatic domain sequence of the megasynthase and the position of the amino acid building blocks in the peptide product, this colinearity rule is not strictly reinforced in nature 36,37

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10.1161/Circulationaha.106.676890 Circulation 101 TadokoroT.IkedaM.IdeT.DeguchiH.IkedaS.OkabeK.et al (2020)

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Furthermore, we tested the lysosomal injury using acridine orange, an acidophilic dye that stains lysosomes 15