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Among the JAM proteins, JAM-A is the best characterized in the regulation of TJ barrier function

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The exogenous ROS burden creates an oxidatively stressed environment mainly by generating intracellular H 2 O 2 , which acts as a second messenger in cell signalling pathways

Lab Invest 47:471476 Acknowledgements We wish to thank Professor Ann Smith for the initial suggestion to investigate the interaction of glutathione with heme