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According to experiments by Zhu et al., TMAO improved the expression of adenosine diphosphate (ADP) and thrombin to enhance a release of Ca 2+ from intracellular calcium stores, causing platelet aggregation and enhancing thrombosis potential (88)

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Furthermore, people who are pregnant, infants, and those who are critically injured or ill may need more arginine than they can produce on their own

Int J Mol Sci (2019) 20:1811

[DOI] [PubMed] [Google Scholar] 63.Kashima T, Rao N, David CJ, Manley JL

Retinopathy and peripheral neuropathy are specific to long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) and mitochondrial trifunctional protein (MTP) deficiency [2, 4, 5]