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No overall differences in safety or efficacy were detected between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out

[DOI] [PubMed] [Google Scholar] 141.Kim E.K., Kim K.A., Lee C.Y., Kim S., Chang S., Cho B.C., Shim H.S

& Hoffman, A

Moreover, it was demonstrated that activation was restricted not only to the luminal venous endothelium but also the endothelium in the vasa vasora of refluxing saphenous veins, as indicated by the upregulation of ICAM-1 [100]

Activation of cleaved form of caspase 3 and PARP was also partially blocked by cPTIO suggesting the role of NO in apoptosis
