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Given this wide-ranging protective role, low levels of glutathione have been shown to be incompatible with optimum health

The enzyme mediates the electron transfers required to regenerate the disulfide bridge of the lipoyl group of dihydrolipoyl transacetylase, that is, to restore the oxidized form of the prosthetic group, thus completing the catalytic cycle of the transacetylase

Role of mitochondria in toxic oxidative stress