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Additionally, the LUAD GWAS in East Asian (EA) populations identified 12 novel variants, while a trans-ancestry meta-analysis between EA and European (EUR) populations discovered 4 new variants

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Desensitisation: Prolonged use can lead to desensitization of the Leydig cells, reducing the effectiveness of HCG over time

doi: 10.1186/s12931-016-0423-7
