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It is naturally produced by your body and widely studied

Tan, X., van Egmond, L., Chapman, C
[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Michikawa M, Fan QW, Isobe I, Yanagisawa K

2023 Sep 11;64(6):453-459

1 Environmental or metabolic stressors, including nutritional state, physical activity, hormonal regulation, and pathological conditions such as heart failure, cancer cachexia, and chronic liver disease, require appropriate fuel selection to maintain metabolic homeostasis

[4] Its detection in blood or urine is associated with a higher risk of kidney impairment
