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Donepezil, rivastigmine, and galantamine are the three drugs in this class that have FDA clearance for the treatment of AD

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Female rats barely make this protein, and humans don't make it at all so this effect cannot happen to us

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In addition, stimulated AngII produces ROS which in turn causes mitochondrial dysfunction, mitochondrial DNA lesions, heart failure, fibrosis, and cardiac hypertrophy (Dai et al